Self‐Targeted Co‐Delivery of an Antibiotic and a Cancer‐Chemotherapeutic from Synthetic Liposomes for the Treatment of Infected Tumors

Intra-tumor bacteria promote tumor growth and inactivate cancer-chemotherapeutics, causing poor treatment prognoses. Combined administration of cancer-chemotherapeutics antibiotics may disturb the oral intestinal microflora in critically-ill patients. To establish intra-tumor co-delivery antibiotics, gemcitabine ciprofloxacin are loaded so-called “self-targeting”, highly blood-compatible, synthetic DCPA-H2O liposomes equipped with complexed water for pH-responsiveness. Liposomal pH-responsiveness can be maintained by in-shell loading in-core ciprofloxacin. These dual-loaded stealthily transported blood circulation to accumulate acidic environment an infected tumor. Upon self-targeting, fused cells infecting disassembled simultaneously release Treatment mice these self-targeting yields significantly higher responses Escherichia coli tumors respect both infection volume than co-delivered from non-self-targeting or free without solution.